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KMID : 0358320140550100629
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Korean Journal of Urology
2014 Volume.55 No. 10 p.629 ~ p.635
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Current Status of Radical Prostatectomy for High-Risk Prostate Cancer
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Kang Ho-Won
Lee Joo-Yong
Kwon Jong-Kyou
Jeh Seong-Uk
Jung Hae-Do
Choi Young-Deuk
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Abstract
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Despite the wide application of prostate-specific antigen-based screening leading to a profound stage migration in prostate cancer (PC), a significant percentage of men are still being diagnosed with clinically high-risk disease that requires aggressive treatment. Optimal management in these patients remains challenging, and strong advocates for radical prostatectomy (RP), radiotherapy, androgen deprivation therapy, and, increasingly, a multimodal approach abound. Currently, surgery for high-risk PC is frequently applied. RP offers an attractive opportunity for tumor excision either as a definitive management or as a first step in multimodal therapy. Nevertheless, this approach is still controversial. In this review, we discuss the current evidence for the role of RP in this clinical setting, including surgical considerations and outcomes. The role of robot-assisted RP, which is increasingly utilized in Korea in this clinical scenario, is discussed.
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KEYWORD
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Prostatectomy, Prostatic neoplasms, Survival, Treatment outcome
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